Cancer-specific T cells are required for effective anti-cancer immunity and have a central role
in cancer immunotherapy. However, emerging evidence suggests that only a small fraction …

Chronic antigen exposure during viral infection or cancer promotes an exhausted T cell (Tex)
state with reduced effector function. However, whether all antigen-specific T cell clones …

Cell cycle (CC) facilitates cell division via robust, cyclical gene expression. Protective
immunity requires the expansion of pathogen-responsive cell types, but whether CC confers …

Lack of immunological tolerance against self-antigens results in autoimmune disorders.
During onset of autoimmunity, dendritic cells (DCs) are thought to be critical for priming of self-…

Adenosine (Ado) mediates immune suppression in the tumor microenvironment and
exhausted CD8 + CAR-T cells express CD39 and CD73, which mediate proximal steps in Ado …

To survive antibiotics, bacteria use two different strategies: counteracting antibiotic effects
by expression of resistance genes or evading their effects eg by persisting inside host cells. …

Many of our daily decisions are memory based, that is, the attribute information about the
decision alternatives has to be recalled. Behavioral studies suggest that for such decisions we …

… (a) Kaplan–Meier plot showing the survival of control and untreated or ABX-treated DC-LMP1/CD40
animals on C57BL/6 and Rag1 −/− background (n≥6). (b) DC-LMP1/CD40 mice …

Inonotus hispidus is used as a traditional medicine in China. Previous investigations
revealed promising immunomodulatory activity of fruit body extracts of I. hispidus. Bioactivity-guided …

Pediatric gliomas comprise a broad range of brain tumors derived from glial cells. While high-grade
gliomas are often resistant to therapy and associated with a poor outcome, children …