Invasive Staphylococcus aureus infections are common, causing high mortality, compounded
by the propensity of the bacterium to develop drug resistance. S. aureus is an excellent …

Background. Early virological failure of antiretroviral therapy associated with the selection of
drug-resistant human immunodeficiency virus type 1 in treatment-naive patients is very …

During severe infections, Staphylococcus aureus moves from its colonising sites to blood
and tissues and is exposed to new selective pressures, thus, potentially driving adaptive …

Background Large-scale genomic studies of within-host diversity in Staphylococcus aureus
bacteraemia (SAB) are needed to understanding bacterial adaptation underlying persistence …

Resistance to meticillin and vancomycin in Staphylococcus aureus significantly complicates
the management of severe infections like bacteraemia, endocarditis or osteomyelitis. Here, …

Antistaphylococcal penicillins such as oxacillin are the key antibiotics in the treatment of
invasive methicillin-susceptible Staphylococcus aureus (MSSA) infections; however, mec gene-…

Background Enterovirus (EV) is the most frequent cause of aseptic meningitis (AM). Lack of
microbiological documentation results in unnecessary antimicrobial therapy and …

Acquisition of PBP2a (encoded by the mec gene) is the key resistance mechanism to β-lactams
in Staphylococcus aureus. The mec gene can be easily detected by PCR assays; …

Objectives We aimed at determining whether specific S. aureus strains cause infective
endocarditis (IE) in the course of Staphylococcus aureus bacteraemia (SAB). Methods A genome-…

Introduction: Management of invasive Staphylococcus aureus infections is complex. Dramatic
improvements in bacterial whole genome sequencing (WGS) offer new opportunities for …