The use of type I interferons (IFNs) in cancer therapy has been limited by ineffective dosing
and significant toxicity. Here, we exploited the tumor-homing ability of proangiogenic Tie2-…

Background Glioblastoma is a highly vascularised tumour and there are few treatment
options after disease recurrence. Regorafenib is an oral multikinase inhibitor of angiogenic, …

We investigated the metabolic profile of cancer stem cells (CSC) isolated from patients with
epithelial ovarian cancer. CSC overexpressed genes associated with glucose uptake, …

Glucocorticoid resistance is a major driver of therapeutic failure in T cell acute lymphoblastic
leukemia (T-ALL). Here, we identify the AKT1 kinase as a major negative regulator of the …

Efficient expression of genes transferred by retroviral vectors is a prerequisite for gene therapy,
especially when the biological effect depends on the amount of transgene product. High-…

Ontogenesis of T cells in the thymus is a complex process whose molecular control is poorly
understood. The present study investigated microRNAs involved in human thymocyte …

The long pentraxin PTX3 is a soluble pattern recognition receptor produced by monocytes
and endothelial cells that plays a nonredundant role in inflammation. Several pathologic …

IFNs are highly pleiotropic cytokines also endowed with marked antiangiogenic activity. In this
study, the mRNA expression profiles of endothelial cells (EC) exposed in vitro to IFN-α, IFN…

Cholangiocarcinoma (CCA) is characterized by an abundant stromal reaction. Cancer‐associated
fibroblasts (CAFs) are pivotal in tumor growth and invasiveness and represent a …

Metabolic rearrangements are essential to satisfy the different requirements of cancer cells
during tumorigenesis and recent studies have highlighted a role for such metabolic …