Neural organoids have the potential to improve our understanding of human brain development
and neurological disorders. However, it remains to be seen whether these tissues can …

Cerebral organoids, or brain organoids, can be generated from a wide array of emerging
technologies for modeling brain development and disease. The fact that they are cultured in …

The human brain has undergone rapid expansion since humans diverged from other great
apes, but the mechanism of this human-specific enlargement is still unknown. Here, we use …

Expansion of the neocortex is thought to underpin the higher cognitive abilities of a number
of mammalian lineages, such as cetaceans, elephants, and primates, with humans exhibiting …

The proteasome, the major protein-degradation machine in cells, regulates neuronal synapses
and long-term information storage. Here, using super-resolution microscopy, we found …

Neurons continuously adapt to external cues and challenges, including stimulation, plasticity-inducing
signals and aging. These adaptations are critical for neuronal physiology and …

Neurons build synaptic contacts using different protein combinations that define the specificity,
function, and plasticity potential of synapses; however, the diversity of synaptic proteomes …

During brain development, axons must extend over great distances in a relatively short amount
of time. How the subcellular architecture of the growing axon sustains the requirements …

Gaining a mechanistic understanding of the molecular pathways underpinning cellular and
organismal physiology invariably relies on the perturbation of an experimental system to infer …

The major protein-degradation machine, the proteasome, functions at brain synapses and
regulates long-term information storage. Here we found that the two essential subcomplexes …