User profiles for Stefano Maffini
Stefano MaffiniMax Planck Institute of Molecular Physiology, Dortmund (Germany) Verified email at mpi-dortmund.mpg.de Cited by 2125 |
Basis of catalytic assembly of the mitotic checkpoint complex
In mitosis, for each daughter cell to inherit an accurate copy of the genome from the mother
cell, sister chromatids in the mother cell must attach to microtubules emanating from opposite …
cell, sister chromatids in the mother cell must attach to microtubules emanating from opposite …
A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint
10.7554/eLife.05269.001 The spindle assembly checkpoint (SAC) monitors and promotes
kinetochore–microtubule attachment during mitosis. Bub1 and BubR1, SAC components, …
kinetochore–microtubule attachment during mitosis. Bub1 and BubR1, SAC components, …
The pseudo GTPase CENP-M drives human kinetochore assembly
10.7554/eLife.02978.001 Kinetochores, multi-subunit complexes that assemble at the interface
with centromeres, bind spindle microtubules to ensure faithful delivery of chromosomes …
with centromeres, bind spindle microtubules to ensure faithful delivery of chromosomes …
Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation
In budding yeast, the Rad9 protein is an important player in the maintenance of genomic
integrity and has a well-characterised role in DNA damage checkpoint activation. Recently, …
integrity and has a well-characterised role in DNA damage checkpoint activation. Recently, …
CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore‐microtubule dynamics to promote mitotic progression and fidelity
Accurate chromosome segregation during mitosis requires precise coordination of various
processes, such as chromosome alignment, maturation of proper kinetochore–microtubule (…
processes, such as chromosome alignment, maturation of proper kinetochore–microtubule (…
[PDF][PDF] Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux
Efficient chromosome segregation during mitosis relies on the coordinated activity of
molecular motors with proteins that regulate kinetochore attachments to dynamic spindle …
molecular motors with proteins that regulate kinetochore attachments to dynamic spindle …
[PDF][PDF] BUB1 and CENP-U, primed by CDK1, are the main PLK1 kinetochore receptors in mitosis
Reflecting its pleiotropic functions, Polo-like kinase 1 (PLK1) localizes to various sub-cellular
structures during mitosis. At kinetochores, PLK1 contributes to microtubule attachments and …
structures during mitosis. At kinetochores, PLK1 contributes to microtubule attachments and …
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
By phosphorylating Thr3 of histone H3, Haspin promotes centromeric recruitment of the
chromosome passenger complex (CPC) during mitosis. Aurora B kinase, a CPC subunit, …
chromosome passenger complex (CPC) during mitosis. Aurora B kinase, a CPC subunit, …
CDC20 assists its catalytic incorporation in the mitotic checkpoint complex
Open (O) and closed (C) topologies of HORMA-domain proteins are respectively associated
with inactive and active states of fundamental cellular pathways. The HORMA protein O-…
with inactive and active states of fundamental cellular pathways. The HORMA protein O-…
Decoding the centromeric nucleosome through CENP-N
10.7554/eLife.33442.001 Centromere protein (CENP) A, a histone H3 variant, is a key
epigenetic determinant of chromosome domains known as centromeres. Centromeres nucleate …
epigenetic determinant of chromosome domains known as centromeres. Centromeres nucleate …