The Rif1 protein, originally identified as a telomere-binding factor in yeast, has recently been
implicated in DNA replication control from yeast to metazoans. Here, we show that budding …

Accessible chromatin is important for RNA polymerase II recruitment and transcription initiation
at eukaryotic promoters. We investigated the mechanistic links between promoter DNA …

Precise nucleosome organization at eukaryotic promoters is thought to be generated by
multiple chromatin remodeler (CR) enzymes and to affect transcription initiation. Using an …

Background: Many academic medical centres have introduced strategies to assess the
productivity of faculty as part of compensation schemes. We conducted a systematic review of the …

Serum and glucocorticoid regulated kinase 1 (Sgk1) is a serine–threonine kinase that is
activated by serum, steroids, insulin, vasopressin, and interleukin 2 at the transcriptional and …

Yeast telomeres comprise irregular TG 1-3 DNA repeats bound by the general transcription
factor Rap1. Rif1 and Rif2, along with Rap1, form the telosome, a protective cap that inhibits …

Background Lung cancer represents the most frequent cause of death for cancer. In non-small
cell lung cancer (NSCLC), which accounts for the vast majority of this disease, only early …

In yeast, Rif1 is part of the telosome, where it inhibits telomerase and checkpoint signaling
at chromosome ends. In mammalian cells, Rif1 is not telomeric, but it suppresses DNA end …

The yeast Sfp1 protein regulates both cell division and growth but how it coordinates these
processes is poorly understood. We demonstrate that Sfp1 directly controls genes required …

Rap1-interacting factor 1 (Rif1) was originally identified in the budding yeast Saccharomyces
cerevisiae as a telomere-binding protein that negatively regulates telomerase-mediated …