Widespread demyelination and axonal loss are the pathological hallmarks of multiple sclerosis.
The multifocal nature of this chronic inflammatory disease of the central nervous system …

Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …

Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into
their microenvironment. Recent studies have elucidated the role of EVs in intercellular …

Cell renewal in the adult central nervous system (CNS) is limited, and is blocked in inflammatory
brain conditions. We show that both neurogenesis and oligodendrogenesis of adult …

Recent evidence shows that transplantation of neural stem/precursor cells may protect the
central nervous system from inflammatory damage through a 'bystander' mechanism that is …

In degenerative disorders of the central nervous system (CNS), transplantation of neural
multipotent (stem) precursor cells (NPCs) is aimed at replacing damaged neural cells 1 , 2 . …

Background Although macrophages (MΦ) are known as essential players in wound healing,
their contribution to recovery from spinal cord injury (SCI) is a subject of debate. The …

Compelling evidence exists that non-haematopoietic stem cells, including mesenchymal (MSCs)
and neural/progenitor stem cells (NPCs), exert a substantial beneficial and therapeutic …

Recent evidence suggests that neural stem/precursor cells (NPCs) promote recovery in
animal models with delayed neuronal death via a number of indirect bystander effects. A …

The well regulated activities of microglia and T cells specific to central nervous system (CNS)
antigens can contribute to the protection of CNS neural cells and their renewal from adult …