Traumatic brain injury (TBI) affects millions of people worldwide every year. The primary
impact initiates the secretion of pro- and anti-inflammatory factors, subsequent recruitment of …

Microglia, the resident immune cells of the central nervous system (CNS), monitor the brain
for disturbances of tissue homeostasis by constantly moving their fine processes. Microglia …

Microglia, the resident immune cells of the central nervous system, exist in either a “resting”
state associated with physiological tissue surveillance or an “activated” state in …

Background Millions of people experience traumatic brain injury (TBI) as a result of falls, car
accidents, sports injury, and blast. TBI has been associated with the development of …

Microglia, the immune cells of the central nervous system, constantly survey the parenchyma
in the healthy brain to maintain homeostasis. When a disturbance, such as cell death, …

CX3CR1, one of the highest expressed genes in microglia in mice and humans, is implicated
in numerous microglial functions. However, the molecular mechanisms underlying Cx3cr1 …

In traumatic brain injury (TBI), a diversity of brain resident and peripherally derived myeloid
cells have the potential to worsen damage and/or to assist in healing. We define the …

Diabetic retinopathy, a microvascular disease characterized by irreparable vascular damage,
neurodegeneration and neuroinflammation, is a leading complication of diabetes mellitus. …

Microglia are motile immune-competent cells of the central nervous system. They assume a
highly branched morphology and monitor the brain parenchyma under physiological …

Identifying molecular mediators of neural circuit development and/or function that contribute
to circuit dysfunction when aberrantly reengaged in neurological disorders is of high …