Human immunodeficiency virus type 1 (HIV-1) displays the unique ability to infect nondividing
cells. The capsid of HIV-1 is the viral determinant for viral nuclear import. To understand …

Retroviral replication proceeds through obligate integration of the viral DNA into the host
genome. In particular, for the HIV-1 genome to enter the nucleus, it must be led through the …

The potential of tumor three-dimensional (3D) in vitro models for the validation of existing or
novel anti-cancer therapies has been largely recognized. During the last decade, diverse in …

The complexity of the central nervous system (CNS) requires researchers to consider all the
variables linked to the interaction between the different cell inhabitants. On this basis, any in …

We here investigated the dynamic cell-to-cell interactions between tumor and mesenchymal
stromal/stem cells (MSCs) by the novel VITVO Ⓡ 3D bioreactor that was customized to …

Background Three-dimensional (3D) cell cultures are the new frontier for reproducing the
tumor micro-environment in vitro. The aims of the study were (1) to establish primary 3D cell …

Background: Three-dimensional (3D) cell cultures are the new frontier for reproducing the
tumor micro-environment in vitro. The aims of the study were (1) to establish primary 3D cell …

Cell-based therapies offer a relevant clinical option for the treatment of cancers which cannot
be fought by conventional drugs [1]. Pre-clinical evaluation of cell-based drug approaches …

Development of a complex multi-layered cell structure using a novel hand-held bioreactor Page
1 Application Note 7 Bioreactors help to bridge the bench to bedside clinical translation of …

HIV-1 displays the unique ability to infect non-dividing cells. The capsid of HIV-1 is the viral
determinant for viral nuclear import. To understand the cellular factors involved in the ability …