Genetic and molecular studies on the expression of Antennapedia (Antp) have suggested
that this gene specifies mainly the second thoracic segment. On the basis of our molecular …

The disulfide reducing enzymes glutathione reductase and thioredoxin reductase are highly
conserved among bacteria, fungi, worms, and mammals. These proteins maintain …

We describe a collection of P-element insertions that have considerable utility for generating
custom chromosomal aberrations in Drosophila melanogaster. We have mobilized a pair of …

Circadian rhythms can be entrained by light to follow the daily solar cycle. In Drosophila
melanogaster a pair of extraretinal eyelets expressing immunoreactivity to Rhodopsin 6 each …

To study the function of the neuropeptide pigment-dispersing factor (PDF) in the circadian
system of Drosophila, we misexpressed the pdf gene from the grasshopperRomalea in the …

Friedreich's ataxia (FRDA) is the most common form of autosomal recessive ataxia caused
by a deficit in the mitochondrial protein frataxin. Although demyelination is a common …

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra pars compacta. Some of the inherited forms of the disease are caused …

Drosophila melanogaster has contributed significantly to the understanding of disease
mechanisms in Parkinson's disease ( PD ) as it is one of the very few PD model organisms that …

A growing body of evidence suggests that oxidative stress is a common underlying mechanism
in the pathogenesis of neurodegenerative disorders such as Alzheimer's, Huntington's, …

Mutations in the ninaA gene of Drosophila severely reduce the amount of rhodopsin specifically
in R1-6 photoreceptors. Isolation of the ninaA gene by chromosomal walking revealed …