Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …

We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in wastewater has been
used to track community infections of coronavirus disease-2019 (COVID-19), providing critical …

Abstract Knowledge of the underpinnings of cancer initiation, progression and metastasis has
increased exponentially in recent years. Advanced “omics” coupled with machine learning …

The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common
Fund program with the goal of generating a large-scale and comprehensive catalogue of …

Background Cell lines have been widely used in biomedical research. The community-based
Cell Line Ontology (CLO) is a member of the OBO Foundry library that covers the domain …

Glioblastoma multiforme (GBM) is the most malignant primary adult brain tumor. The current
standard of care is surgical resection, radiation, and chemotherapy treatment, which extends …

Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high-…

PPARγ is the functioning receptor for the thiazolidinedione (TZD) class of antidiabetes drugs
including rosiglitazone and pioglitazone 1 . These drugs are full classical agonists for this …

National Institutes of Health (NIH)-sponsored screening centers provide academic researchers
with a special opportunity to pursue small-molecule probes for protein targets that are …