Neurotransmitters are released at presynaptic active zones (AZs). In the fly Drosophila,
monoclonal antibody (MAB) nc82 specifically labels AZs. We employ nc82 to identify Bruchpilot …

The molecular organization of presynaptic active zones during calcium influx–triggered
neurotransmitter release is the focus of intense investigation. The Drosophila coiled-coil domain …

Aging is associated with an increased risk of cardiovascular disease and death. Here we
show that oral supplementation of the natural polyamine spermidine extends the lifespan of …

During the past years, yeast has been successfully established as a model to study mechanisms
of apoptotic regulation. However, the beneficial effects of such a cell suicide program …

Oxygen radicals are important components of metazoan apoptosis. We have found that
apoptosis can be induced in the yeast Saccharomyces cerevisiae by depletion of glutathione or …

… Lä chelt,1 Mark Herlan,2 Markus Fehr,3 Kirsten Lauber,4 Stephan J. Sigrist,5 markers of
apoptosis such as DNA fragmentation, phosSebastian Wesselborg,4 and Kai-Uwe Frohlich6 …

We demonstrate that fizzy-related (fzr), a conserved eukaryotic gene, negatively regulates
the levels of cyclins A, B, and B3. These mitotic cyclins that bind and activate cdk1(cdc2) are …

Apoptosis-inducing factor (AIF), a key regulator of cell death, is essential for normal mammalian
development and participates in pathological apoptosis. The proapoptotic nature of AIF …

Synaptic vesicles fuse at active zone (AZ) membranes where Ca 2+ channels are clustered
and that are typically decorated by electron-dense projections. Recently, mutants of the …

Endonuclease G (EndoG) is located in mitochondria yet translocates into the nucleus of
apoptotic cells during human degenerative diseases. Nonetheless, a direct involvement of …