The need for rapid, accurate, and scalable testing systems for COVID-19 diagnosis is clear
and urgent. Here, we report a rapid Scalable and Portable Testing (SPOT) system consisting …

Genome editing critically relies on selective recognition of target sites. However, despite
recent progress, the underlying search mechanism of genome-editing proteins is not fully …

Plasmids are used extensively in basic and applied biology. However, design and construction
of plasmids, specifically the ones carrying complex genetic information, remains one of …

The CRISPR/Cas system has emerged as a powerful tool for genome editing in metabolic
engineering and human gene therapy. However, locating the optimal site on the chromosome …

The Argonaute protein from the archaeon Pyrococcus furiosus (PfAgo) is a DNA-guided
nuclease that targets DNA with any sequence. We designed a virus detection assay in which the …

To efficiently ferment intermediate cellodextrins released during cellulose hydrolysis,
Saccharomyces cerevisiae has been engineered by introduction of a heterologous cellodextrin …

Several viruses infect the mammalian central nervous system (CNS), some with devastating
consequences, others resulting in chronic or persistent infections associated with little or no …

The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human
suffering. To date, no effective drug is available to directly treat the disease. In a search for …

The innate immune system is strongly implicated in the pathogenesis of Alzheimer’s disease
(AD). In contrast, the role of adaptive immunity in AD remains largely unknown. However, …

Infection of C57BL/6 mice with mouse hepatitis virus (MHV) results in a demyelinating
encephalomyelitis characterized by mononuclear cell infiltration and white matter destruction …