Common fragile sites have long been identified by cytogeneticists as chromosomal regions
prone to breakage upon replication stress 1 . They are increasingly recognized to be …

Correct replication of the genome and protection of its integrity are essential for cell survival.
In a high-throughput screen studying H2AX phosphorylation, we identified Wee1 as a …

The interplay between replication stress and the S phase checkpoint is a key determinant of
genome maintenance, and has a major impact on human diseases, notably, tumour …

Faithful DNA replication is essential for the maintenance of genome integrity. Incomplete
genome replication leads to DNA breaks and chromosomal rearrangements, which are causal …

Breaks at common fragile sites (CFS) are a recognized source of genome instability in pre-neoplastic
lesions, but how such checkpoint-proficient cells escape surveillance and continue …

The subunit that mediates binding of proliferating cell nuclear antigen (PCNA) to human DNA
polymerase δ has not been clearly defined. We show that the third subunit of human DNA …

The factors that govern replication programs are still poorly identified in metazoans, especially
in mammalian cells. Thanks to molecular combing, the dynamics of DNA replication can …

Proliferating cell nuclear antigen is best known as a DNA polymerase accessory protein but
has more recently also been shown to have different functions in important cellular …

Mammalian cells deficient in ATR or Chk1 display moderate replication fork slowing and
increased initiation density, but the underlying mechanisms have remained unclear. We show …

Cyclin-dependent kinase (Cdk) Cdk1–Cyclin A can phosphorylate Flap endonuclease 1 (Fen1),
a key-enzyme of the DNA replication machinery, in late S phase. Cdk1–cyclin A forms a …