Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome
and the leading cause of chronic liver disease in the Western world. Twenty per cent of …

Macrophages have an important role in the maintenance of tissue homeostasis 1 . To perform
this function, macrophages must have the capacity to monitor the functional states of their ‘…

Inflammasomes are multiprotein complexes that function as sensors of endogenous or
exogenous damage-associated molecular patterns. Here, we show that deficiency of NLRP6 in …

Aluminium adjuvants, typically referred to as ‘alum’, are the most commonly used adjuvants
in human and animal vaccines worldwide, yet the mechanism underlying the stimulation of …

Allergic asthma is an inflammatory lung disease initiated and directed by T helper cells type
2 (Th2). The mechanism involved in generation of Th2 responses to inert inhaled antigens, …

Inhalation of crystalline silica and asbestos is known to cause the progressive pulmonary
fibrotic disorders silicosis and asbestosis, respectively. Although alveolar macrophages are …

Nlrp3 inflammasome activation occurs in response to numerous agonists but the specific
mechanism by which this takes place remains unclear. All previously evaluated activators of the …

Dying cells are capable of activating the innate immune system and inducing a sterile
inflammatory response. Here, we show that necrotic cells are sensed by the Nlrp3 inflammasome …

The spleen is the largest secondary lymphoid organ in the body and, as such, hosts a wide
range of immunologic functions alongside its roles in hematopoiesis and red blood cell …

Chronic inflammation is a known risk factor for tumorigenesis, yet the precise mechanism of
this association is currently unknown. The inflammasome, a multiprotein complex formed by …