Background Despite decreases in incidence and related mortality, malaria remains a major
public health challenge in the Greater Mekong Sub-region (GMS). The emergence of …

The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-cyclic
guanosine monophosphate (cGMP) are intracellular messengers found in most animal cell …

Background Over the last 20 years, malaria incidence has decreased across the Greater
Mekong Sub-region (GMS) and the emergence of artemisinin resistance has stimulated efforts …

Fundamental processes that govern the lytic cycle of the intracellular parasite Toxoplasma
gondii are regulated by several signalling pathways. However, how these pathways are …

Cyclic nucleotide signalling is a major regulator of malaria parasite differentiation.
Phosphodiesterase (PDE) enzymes are known to control cyclic GMP (cGMP) levels in the parasite, …

Five species of parasite cause malaria in humans with the most severe disease caused by
Plasmodium falciparum. Many of the proteins encoded in the P. falciparum genome are …

The efficacy of current antimalarial drugs is threatened by reduced susceptibility of Plasmodium
falciparum to artemisinin, associated with mutations in pfkelch13. Another gene with …

During the course of the asexual erythrocytic stage of development, Plasmodium spp. parasites
undergo a series of morphological changes and induce alterations in the host cell. At the …

N-myristoylation is a ubiquitous class of protein lipidation across eukaryotes and N-myristoyl
transferase (NMT) has been proposed as an attractive drug target in several pathogens. …

Guanylyl cyclases (GCs) synthesize cyclic GMP (cGMP) and, together with cyclic nucleotide
phosphodiesterases, are responsible for regulating levels of this intracellular messenger …