Mice deficient for all ten-eleven translocation (TET) genes exhibit early gastrulation lethality.
However, separating cause and effect in such embryonic failure is challenging. To isolate …

Exploiting multiple mouse tumor models including a unique GEMM-derived allograft system
in combination with preclinical therapy designs closely matching the human situation, this …

The angiopoietin (Ang)–Tie pathway has been intensely pursued as candidate second‐generation
anti‐angiogenic target. While much of the translational work has focused on the …

The fetoplacental capillary network is of vital importance for proper nourishment during
early development. Inadequate maternal-fetal circulation has emerged as one of the main …

Background. Despite improvements in prevention and treatment, severe coronavirus
disease 2019 (COVID-19) is associated with high mortality. Phosphoinositide 3-kinase (PI3K) …

Interaction between the chemokine receptor CXCR4 and its chief ligand CXCL12 plays a
critical role in the retention and migration of hematopoietic stem and progenitor cells (HSPCs) …

Background Despite improvements in prevention and treatment, severe coronavirus
disease 2019 (COVID-19) is associated with high mortality. Phosphoinositide 3-kinase (PI3K) …

Outcomes in patients with relapsed diffuse large B-cell lymphoma (DLBCL) who undergo
autologous stem cell transplant (auto-SCT) are poor. Blinatumomab is a CD3/CD19 bispecific T…

Mobilized peripheral blood has become the primary source of hematopoietic stem and
progenitor cells (HSPCs) for stem cell transplantation, with a 5-day course of granulocyte colony-…

Introduction: Autologous hematopoietic stem cell transplantation (auto-HCT) is the standard
treatment for patients with chemo-sensitive relapsed/refractory diffuse large B cell lymphoma …