User profiles for Stephanie Halford

Stephanie Halford

University of Oxford
Verified email at eye.ox.ac.uk
Cited by 5985

Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6. 2 (KCNJ11) and SUR1 (ABCC8) confirm that the …

…, M Walker, JC Levy, M Sampson, S Halford… - Diabetes, 2003 - Am Diabetes Assoc
The genes ABCC8 and KCNJ11, which encode the subunits sulfonylurea receptor 1 (SUR1)
and inwardly rectifying potassium channel (Kir6.2) of the β-cell ATP-sensitive potassium (K …

The evolution of irradiance detection: melanopsin and the non-visual opsins

SN Peirson, S Halford… - … Transactions of the …, 2009 - royalsocietypublishing.org
Circadian rhythms are endogenous 24 h cycles that persist in the absence of external time
cues. These rhythms provide an internal representation of day length and optimize physiology …

[PDF][PDF] VA opsin-based photoreceptors in the hypothalamus of birds

S Halford, SS Pires, M Turton, L Zheng… - Current Biology, 2009 - cell.com
Studies in the 1930s demonstrated that birds possess photoreceptors that are located within
the hypothalamus and regulate photoperiodic responses to day length [1, 2]. Most recently, …

Targeted Mutagenesis of the Hira Gene Results in Gastrulation Defects and Patterning Abnormalities of Mesoendodermal Derivatives Prior to Early Embryonic …

…, H Farmer, W Kimber, S Halford… - … and cellular biology, 2002 - Taylor & Francis
The Hira gene encodes a nuclear WD40 domain protein homologous to the yeast transcriptional
corepressors Hir1p and Hir2p. Using targeted mutagenesis we demonstrate that Hira is …

Functional diversity of melanopsins and their global expression in the teleost retina

…, S Hughes, TK Tamai, M Turton, S Halford… - Cellular and Molecular …, 2011 - Springer
Melanopsin (OPN4) is an opsin photopigment that, in mammals, confers photosensitivity to
retinal ganglion cells and regulates circadian entrainment and pupil constriction. In non-…

Large-Scale Analysis of the Relationship between CYP11A Promoter Variation, Polycystic Ovarian Syndrome, and Serum Testosterone

…, S Taponen, AL Hartikainen, S Halford… - The Journal of …, 2004 - academic.oup.com
CYP11A, the gene encoding P450scc, a key enzyme in steroid biosynthesis, is a strong
biological candidate for polycystic ovary syndrome (PCOS) susceptibility. Four of the five …

Unravelling the genetics of inherited retinal dystrophies: Past, present and future

S Broadgate, J Yu, SM Downes, S Halford - Progress in retinal and eye …, 2017 - Elsevier
The identification of the genes underlying monogenic diseases has been of interest to
clinicians and scientists for many years. Using inherited retinal dystrophies as an example of …

Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina

…, RG Foster, MW Hankins, S Halford - Journal of …, 2009 - Soc Neuroscience
Melanopsin is the photopigment that confers photosensitivity to a subset of retinal ganglion
cells (pRGCs) that regulate many non-image-forming tasks such as the detection of light for …

Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43

S Halford, MS Freedman, J Bellingham, SL Inglis… - Genomics, 2001 - Elsevier
As part of an ongoing search to identify novel mammalian photopigments that may mediate
nonvisual tasks such as circadian entrainment and acute suppression of pineal melatonin …

Detailed phenotypic and genotypic characterization of bietti crystalline dystrophy

S Halford, G Liew, DS Mackay, PI Sergouniotis, R Holt… - Ophthalmology, 2014 - Elsevier
… Author links open overlay panel Stephanie Halford PhD 1 ∗∗ , Gerald Liew PhD 2 3 ∗∗ ,
Donna S. Mackay PhD 3 , Panagiotis I. Sergouniotis PhD 3 4 , Richard Holt DPhil 1 , Suzanne …