Numerous inflammatory conditions are associated with elevated YKL‐40 expression by
infiltrating macrophages. Thus, we were surprised to observe minimal macrophage and …

Background Alzheimer’s disease (AD) is characterized by robust microgliosis and phenotypic
changes that accompany disease pathogenesis. Accumulating evidence from genetic …

Background Highly pathogenic H5N1 avian influenza viruses continue to spread via waterfowl,
causing lethal infections in humans. Vaccines can prevent the morbidity and mortality …

Genetic association studies have demonstrated the critical involvement of the microglial
immune response in Alzheimer's disease (AD) pathogenesis. Phospholipase C-gamma-2 (…

Human immunodeficiency virus encephalitis causes dementia in acquired immune deficiency
syndrome patients. Using proteomic analysis of postmortem cerebrospinal fluid (CSF) and …

One of the challenges for developing an H5N1 influenza vaccine is the diversity of
antigenically distinct isolates within this subtype. Previously, our group described a novel …

Severe influenza kills tens of thousands of individuals each year, yet the mechanisms driving
lethality in humans are poorly understood. Here we used a unique translational model of …

YKL-40 (chitinase 3-like protein 1) is expressed in a broad spectrum of inflammatory
conditions and cancers. We have previously reported that YKL-40 levels are elevated in the …

Influenza virus infections cause a wide variety of outcomes, from mild disease to 3 to 5
million cases of severe illness and ∼290,000 to 645,000 deaths annually worldwide. The …

Previous research demonstrated that genetic heterogeneity is a critical factor in modeling
amyloid accumulation and other Alzheimer’s disease phenotypes. However, it is unknown …