[HTML][HTML] Cranberry proanthocyanidins have anti-biofilm properties against Pseudomonas aeruginosa

RK Ulrey, SM Barksdale, W Zhou… - BMC complementary and …, 2014 - Springer
Background Bacteria within a biofilm are phenotypically more resistant to antibiotics, desiccation,
and the host immune system, making it an important virulence factor for many microbes…

Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella …

SM Barksdale, EJ Hrifko, ML van Hoek - Developmental & Comparative …, 2017 - Elsevier
Alligator mississippiensis (American alligator), a member of order Crocodilia, lives in
bacteria-laden environments but is not often known to succumb to bacterial infections. Their serum …

[HTML][HTML] Helical cationic antimicrobial peptide length and its impact on membrane disruption

…, EH Williams, CA Rodriguez, SM Barksdale… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Cationic antimicrobial peptides (CAMPs) are important elements of innate immunity in
higher organisms, representing an ancient defense mechanism against pathogenic bacteria. …

[HTML][HTML] Bioprospecting the American Alligator (Alligator mississippiensis) Host Defense Peptidome

BM Bishop, ML Juba, MC Devine, SM Barksdale… - PLoS …, 2015 - journals.plos.org
Cationic antimicrobial peptides and their therapeutic potential have garnered growing
interest because of the proliferation of bacterial resistance. However, the discovery of new …

[HTML][HTML] Snake Cathelicidin NA-CATH and Smaller Helical Antimicrobial Peptides Are Effective against Burkholderia thailandensis

RJ Blower, SM Barksdale… - PLoS neglected tropical …, 2015 - journals.plos.org
Burkholderia thailandensis is a Gram-negative soil bacterium used as a model organism for
B. pseudomallei, the causative agent of melioidosis and an organism classified category B …

Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo Dragon) by Large-Scale Analyses and De-Novo-Assisted Sequencing Using …

…, PS Russo, M Devine, SM Barksdale… - Journal of proteome …, 2017 - ACS Publications
Komodo dragons are the largest living lizards and are the apex predators in their environs.
They endure numerous strains of pathogenic bacteria in their saliva and recover from …

[HTML][HTML] Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii

SM Barksdale, EJ Hrifko, EMC Chung, ML van Hoek - BMC microbiology, 2016 - Springer
Background Our group has developed a new process for isolating and identifying novel
cationic antimicrobial peptides from small amounts of biological samples. Previously, we …

Intraperitoneal treatment with antimicrobial peptide rescues mice from a pulmonary Francisella infection

ML van Hoek, A Kaushal, BM Bishop, SM Barksdale - bioRxiv, 2019 - biorxiv.org
Our long-term goal is to identify new antimicrobial peptides that might be effective against
pneumonic Francisella infection in mice. Previously, our group searched the peptidome of the …

Pulsatile ACTH secretion: variation with time of day and relationship to cortisol

M Carnes, NH Kalin, SJ Lent, CM Barksdale… - Peptides, 1988 - Elsevier
It has long been known that ACTH is secreted in an episodic fashion demonstrating circadian
and ultradian rhythms. High intensity venous sampling has recently revealed that in …

Episodic secretion of ACTH in rats

…, MS Brownfield, NH Kalin, S Lent, CM Barksdale - Peptides, 1986 - Elsevier
While the circadian rhythm of pituitary adrenocorticotropin (ACTH) secretion has been well
characterized, the ultradian rhythm has been less thoroughly investigated. To study the …