Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely unclear.
Here, acute perturbations (∼1 h) to actomyosin stress or ECM elasticity cause rapid and …

In development and differentiation, morphological changes often accompany mechanical
changes [1], but it is unclear whether or when cells in embryos sense tissue elasticity. The …

Early in embryogenesis, the heart begins its rhythmic contractions as a tube that helps perfuse
the nascent vasculature, but the embryonic heart soon changes shape and mechanical …

The heart is an active material which relies on robust signaling mechanisms between cells
in order to produce well-timed, coordinated beats. Dysfunction in this signaling results in …

In this review, we discuss recent studies on the mechanosensitive morphology and function
of cardiomyocytes derived from embryos and neonates. For early cardiomyocytes cultured …

In development and differentiation, morphological changes often accompany mechanical
changes [1], but it is unclear if or when cells in embryos sense tissue elasticity. The earliest …

This thesis addresses the questions of when and how mechanical stiffness arises during
embryonic heart development and how mechanics affects early cardiomyocyte and …

Healthy heart function and structure, from the tissue to cellular scale, depends on establishment
of proper tissue mechanics. On the cellular scale, late embryonic, neonatal and adult …

Recent studies have demonstrated the effects of cardiomyocyte mechanosensitivity to ECM
elasticity on beating physiology of 10 day chick embryo cardiomyocytes [1] and also of …

The heart is the first organ to develop in vertebrate embryos, and coordinated beating of
cardiomyocytes is likely facilitated by structural proteins of the extracellular matrix, cytoskeleton, …