The structure of a large fragment of the c-Src tyrosine kinase, comprising the regulatory and
kinase domains and the carboxy-terminal tail, has been determined at 1.7 Å resolution in a …

The spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular receptor,
angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on …

Infection by viruses having lipid-bilayer envelopes proceeds through fusion of the viral
membrane with a membrane of the target cell. Viral 'fusion proteins' facilitate this process. They …

The crystallographically determined structure of a soluble fragment from the major envelope
protein of a flavivirus reveals an unusual architecture. The flat, elongated dimer extends in a …

A combinatorial disulfide cross-linking strategy was used to prepare a stalled complex of
human immunodeficiency virus–type 1 (HIV-1) reverse transcriptase with a DNA template:…

A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms
a protein-conducting channel, allowing polypeptides to be transferred across or integrated …

Dengue virus enters a host cell when the viral envelope glycoprotein, E, binds to a receptor
and responds by conformational rearrangement to the reduced pH of an endosome. The …

The yeast transcriptional activator GCN4 is 1 of over 30 identified eukaryotic proteins
containing the basic region leucine zipper (bZIP) DNA-binding motif. We have determined the …

Dengue virus is an emerging global health threat. Its major envelope glycoprotein, E,
mediates viral attachment and entry by membrane fusion. A crystal structure of the soluble …

The inhibitory protein, IκBα, sequesters the transcription factor, NF-κB, as an inactive complex
in the cytoplasm. The structure of the IκBα ankyrin repeat domain, bound to a partially …