Inhibition of epidermal growth factor receptor (EGFR) signaling by small molecule kinase
inhibitors and monoclonal antibodies has proven effective in the treatment of multiple cancers. …

Trastuzumab-emtansine (T-DM1) is an antibody-drug conjugate (ADC) that efficiently
delivers a highly potent microtubule inhibitor to HER2 overexpressing cells. Herein, we utilize …

Metastasis of cancer cells to vital organs remains the leading cause of cancer related deaths,
emphasizing a strong need for actionable targets in advanced stage cancer. To address …

Nanobodies specific for extracellular matrix markers commonly expressed in primary tumors
and metastases are promising agents for noninvasive detection of tumors and metastases …

Viruses have brought humanity many challenges: respiratory infection, cancer, neurological
impairment and immunosuppression to name a few. Virology research over the last 60+ …

Background Medulloblastoma is the most common pediatric brain malignancy. Patients with
the Group 3 subtype of medulloblastoma (MB) often exhibit MYC amplification and/or …

… In a perceptive monograph on Purdy published in 1976, British critic Stephen Adams
noted the "Christian existentialist" philosophic basis of Purdy's work, which he claimed to be "…

Improving mathematical student performance in K-12 education has been a focus in the US
Students in the US score lower on standardized math assessments than students in other …

Waterlogged archaeological sites in Florida contain tools, art objects, dietary items, human
skeletal remains, and glimpses of past environments that do not survive the ravages of time at …

… of Purdy’s historical and racial allegories of America found in these works. I argue that Purdy’s
… , or absent, Purdy regards Natives as central to the formation of a truly American identity. …