Background Maternal infection during pregnancy is associated with an increased risk of
schizophrenia and autism in the offspring. Supporting this correlation, experimentally activating …

Schizophrenia and autism are thought to result from the interaction between a susceptibility
genotype and environmental risk factors. The offspring of women who experience infection …

A common pathological finding in autism is a localized deficit in Purkinje cells (PCs).
Cerebellar abnormalities have also been reported in schizophrenia. Using a mouse model that …

People with autism spectrum disorder are characterized by impaired social interaction,
reduced communication, and increased repetitive behaviors. The disorder has a substantial …

INTRODUCTION Current views of human evolution, as supported by the fossil record,
indicate that many hominin lineage branches arose, but only one survived to the present. …

A subset of central glutamatergic synapses are coordinately pruned and matured by unresolved
mechanisms during postnatal development. We report that the human epilepsy gene …

Genes that are mutated in Autism Spectrum Disorders (ASD) can be classified broadly as
either synaptic or developmental. But what if this is a false distinction? A recent spate of …

Background Sickness during pregnancy is associated with an increased risk of offspring
neurodevelopmental disorders. Rodent models have played a critical role in establishing causal …

The observation that maternal infection increases the risk for schizophrenia in the offspring
suggests that the maternal immune system plays a key role in the etiology of schizophrenia. …

Quantitation of huntingtin protein in the brain is needed, both as a marker of Huntington disease
(HD) progression and for use in clinical gene silencing trials. Measurement of huntingtin …