TRAAK channels, members of the two–pore domain K + (potassium ion) channel family K2P,
are expressed almost exclusively in the nervous system and control the resting membrane …

Mechanosensitive ion channels underlie neuronal responses to physical forces in the
sensation of touch, hearing, and other mechanical stimuli. The fundamental basis of force …

SARS-CoV-2 ORF3a is a putative viral ion channel implicated in autophagy inhibition,
inflammasome activation and apoptosis. 3a protein and anti-3a antibodies are found in infected …

Activation of mechanosensitive ion channels by physical force underlies many physiological
processes including the sensation of touch, hearing and pain 1 , 2 , 3 , 4 , 5 . TRAAK (also …

Tris(2-carboxyethyl)phosphine (TCEP) is a widely used substitute for dithiothreitol (DTT) in
the reduction of disulfide bonds in biochemical systems. Although TCEP has been recently …

Understanding brain function requires technologies that can control the activity of large
populations of neurons with high fidelity in space and time. We developed a multiphoton …

Nuclear pore complexes (NPCs) facilitate nucleocytoplasmic transport. These massive
assemblies comprise an eightfold symmetric scaffold of architectural proteins and central-channel …

Nuclear pore complexes (NPCs) perforate the nuclear envelope and represent the exclusive
passageway into and out of the nucleus of the eukaryotic cell. Apart from their essential …

SARS-CoV-2 encodes four structural proteins incorporated into virions, spike (S), envelope (E),
nucleocapsid (N), and membrane (M). M plays an essential role in viral assembly by …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes the
coronavirus disease 2019 (COVID-19). SARS-CoV-2 encodes three putative ion channels: E…