In our previous work, using a fluorescent adenosine-A 3 receptor (A 3 AR) agonist and
fluorescence correlation spectroscopy (FCS), we demonstrated high-affinity labeling of the active …

Recent years have revealed a high degree of structural organisation in the way in which cell-surface
receptors and their associated signalling complexes interact at a molecular level. …

G protein-coupled receptors control a wide range of physiological processes and are the
target for many clinically used drugs. Understanding the way in which receptors bind agonists …

Background and purpose: The introduction of fluorescence‐based techniques, and in
particular the development of fluorescent ligands, has allowed the study of G protein‐coupled …

G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane proteins.
For GPCR drug discovery, it is important that ligand affinity is determined in the correct …

Fluorescence spectroscopy is becoming a valuable addition to the array of techniques available
for scrutinizing ligand−receptor interactions in biological systems. In particular, scanning …

A growing awareness indicates that many G-protein-coupled receptors (GPCRs) exist as
homodimers, but the extent of the cooperativity across the dimer interface has been largely …

G protein-coupled receptors (GPCRs) are organised within the cell membrane into highly
ordered macromolecular complexes along with other receptors and signalling proteins. …

In recent years, several novel aspects of GPCR pharmacology have been described, which
are thought to play a role in determining the in vivo efficacy of a compound. Fluorescent …

The fundamental importance of membrane proteins in cellular processes has driven a marked
increase in the use of membrane mimetic approaches for studying and exploiting these …