We performed a genome-wide association study (GWAS) in 1,713 individuals of European
ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases …

We conducted a genome-wide association study (GWAS) of breast cancer by genotyping
528,173 SNPs in 1,145 postmenopausal women of European ancestry with invasive breast …

Assessing linkage disequilibrium (LD) across ancestral populations is a powerful approach
for investigating population-specific genetic structure as well as functionally mapping regions …

Recently, common variants on human chromosome 8q24 were found to be associated with
prostate cancer risk. While conducting a genome-wide association study in the Cancer …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for ∼9…

We followed our initial genome-wide association study (GWAS) of 527,869 SNPs on 1,172
individuals with prostate cancer and 1,157 controls of European origin—nested in the Prostate…

Stratification of women according to their risk of breast cancer based on polygenic risk scores
(PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, …

We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer
with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 …

Using a multistage genetic association approach comprising 7,480 affected individuals and
7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal …

Background Mutations in TERC, the gene for the RNA component of telomerase, cause
short telomeres in congenital aplastic anemia and in some cases of apparently acquired …