Microsatellite instability (MSI), the spontaneous loss or gain of nucleotides from repetitive
DNA tracts, is a diagnostic phenotype for gastrointestinal, endometrial, and colorectal tumors, …

To understand the genetic drivers of immune recognition and evasion in colorectal cancer,
we analyzed 1,211 colorectal cancer primary tumor samples, including 179 classified as …

The detection and quantification of genetic heterogeneity in populations of cells is fundamentally
important to diverse fields, ranging from microbial evolution to human cancer genetics. …

BACKGROUND Microsatellite instability (MSI) is a useful phenotype in cancer diagnosis
and prognosis. Nevertheless, methods to detect MSI status from next generation DNA …

High-throughput sequencing of the taxonomically informative 16S rRNA gene provides a
powerful approach for exploring microbial diversity. Here we compare the performances of two …

Nosocomial infections pose a significant threat to patient health; however, the gold standard
laboratory method for determining bacterial relatedness (pulsed-field gel electrophoresis […

To catalog protein-altering mutations that may drive the development of prostate cancers
and their progression to metastatic disease systematically, we performed whole-exome …

A hypermutated subtype of advanced prostate cancer was recently described, but prevalence
and mechanisms have not been well-characterized. Here we find that 12% (7 of 60) of …

Recent years have seen development and implementation of anticancer therapies targeted
to particular gene mutations, but methods to assay clinical cancer specimens in a …

Mutations in ELA2 encoding the neutrophil granule protease, neutrophil elastase (NE), are
the major cause of the 2 main forms of hereditary neutropenia, cyclic neutropenia and severe …