ATP-sensitive potassium channels (K-ATP channels) couple cell metabolism to electrical
activity and are important in the physiology and pathophysiology of many tissues 1 . In …

Adenosine triphosphate (ATP)–sensitive potassium (K ATP ) channels couple electrical
activity to cellular metabolism through their inhibition by intracellular ATP. ATP inhibition of K …

Migraine with aura is a common, debilitating, recurrent headache disorder associated with
transient and reversible focal neurological symptoms 1 . A role has been suggested for the two…

There has been considerable debate as to whether adenosine triphosphate (ATP) is
compartmentalized within cells and, in particular, whether the ATP concentration directly beneath …

Sulfonylureas stimulate insulin secretion from pancreatic beta-cells by closing ATP-sensitive
K+ (K(ATP)). The beta-cell and cardiac muscle K(ATP) channels have recently been cloned …

TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by multiple
stimuli such as stretch, fatty acids, and pH and by several drugs. However, the mechanisms …

The ATP-sensitive K-channel (K-ATP channel) plays a key role in insulin secretion from
pancreatic β-cells. It is closed by glucose metabolism, which stimulates insulin secretion, and …

Biological ion channels are nanoscale transmembrane pores. When water and ions are
enclosed within the narrow confines of a sub-nanometer hydrophobic pore, they exhibit …

Two‐pore domain (K2P) potassium channels are important regulators of cellular electrical
excitability. However, the structure of these channels and their gating mechanism, in particular …

Two-pore domain (K2P) K + channels are major regulators of excitability that endow cells
with an outwardly rectifying background "leak" conductance. In some K2P channels, strong …