WITH increasing frequency, the human neutrophil is being implicated as a mediator of tissue-destructive
events in inflammatory diseases ranging from rheumatoid arthritis and …

The Polycomb Group Protein EZH2 is a transcriptional repressor involved in controlling
cellular memory and has been linked to aggressive prostate cancer. Here we investigate the …

Cancer cells are able to proliferate at accelerated rates within the confines of a three-dimensional
(3D) extracellular matrix (ECM) that is rich in type I collagen. The mechanisms used by …

Cell migration through 3D tissue depends on a physicochemical balance between cell
deformability and physical tissue constraints. Migration rates are further governed by the capacity …

Movement of neutrophils from the bloodstream to inflamed tissue depends on the activation
of both the neutrophil and the endothelial cell. Endothelial cells lining the postcapillary …

The model hydrogen peroxide-myeloperoxidase-chloride system is capable of generating
the powerful oxidant hypochlorous acid, which can be quantitated by trapping the generated …

During angiogenesis, endothelial cells penetrate fibrin barriers via undefined proteolytic
mechanisms. We demonstrate that the fibrinolytic plasminogen activator (PA)-plasminogen …

HUMAN stromelysin-3, a new member of the matrix metalloproteinase family, is expressed in
tissues undergoing the active remodelling associated with embryonic development, wound …

Accumulating evidence indicates that hyperactive Wnt signalling occurs in association with
the development and progression of human breast cancer. As a consequence of engaging …

Tissue invasion during metastasis requires cancer cells to negotiate a stromal environment
dominated by cross-linked networks of type I collagen. Although cancer cells are known to …