The levels of hypoxia-inducible factor 1α (HIF-1α) are tightly controlled. Here, we investigated
the posttranscriptional regulation of HIF-1α expression in human cervical carcinoma HeLa …

Recent studies indicate that extracellular vesicles are an important source material for many
clinical applications, including minimally-invasive disease diagnosis. However, challenges …

Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is a nucleocytoplasmic shuttling protein
that regulates gene expression through its action on mRNA metabolism and translation. …

Translation of the X-linked inhibitor of apoptosis (XIAP) proceeds by internal ribosome entry
site (IRES)-mediated initiation, a process that is physiologically important because XIAP …

Apoptosis can be regulated by extracellular signals that are communicated by peptides such
as fibroblast growth factor 2 (FGF-2) that have important roles in tumor cell proliferation. The …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated with the
progressive death of motor neurons. Mean survival for a patient diagnosed with ALS is between …

DAP5/p97 is a member of the eIF4G family of translation initiation factors that has been
suggested to play an important role in the translation of select messenger RNA molecules. We …

Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a stress granule-associated
RNA-binding protein that plays a role in apoptosis and cellular stress recovery. HnRNP A1 is a …

Internal ribosome entry sites (IRES) allow ribosomes to be recruited to mRNA in a cap-independent
manner. Some viruses that impair cap-dependent translation initiation utilize IRES to …

Cell-derived extracellular vesicles (EVs) participate in cell-cell communication via transfer of
molecular cargo including genetic material like miRNAs. In mammals, it has previously …