User profiles for Stephen M. Lewis
Stephen M. LewisScientific Director, Atlantic Cancer Research Institute Verified email at canceratl.ca Cited by 2361 |
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1α
The levels of hypoxia-inducible factor 1α (HIF-1α) are tightly controlled. Here, we investigated
the posttranscriptional regulation of HIF-1α expression in human cervical carcinoma HeLa …
the posttranscriptional regulation of HIF-1α expression in human cervical carcinoma HeLa …
[HTML][HTML] Rapid isolation of extracellular vesicles from cell culture and biological fluids using a synthetic peptide with specific affinity for heat shock proteins
A Ghosh, M Davey, IC Chute, SG Griffiths, S Lewis… - PloS one, 2014 - journals.plos.org
Recent studies indicate that extracellular vesicles are an important source material for many
clinical applications, including minimally-invasive disease diagnosis. However, challenges …
clinical applications, including minimally-invasive disease diagnosis. However, challenges …
Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein A1 controls translation initiation of specific mRNAs
Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is a nucleocytoplasmic shuttling protein
that regulates gene expression through its action on mRNA metabolism and translation. …
that regulates gene expression through its action on mRNA metabolism and translation. …
Subcellular Relocalization of a Trans-acting Factor Regulates XIAP IRES-dependent Translation
SM Lewis, A Veyrier… - Molecular biology of …, 2007 - Am Soc Cell Biol
Translation of the X-linked inhibitor of apoptosis (XIAP) proceeds by internal ribosome entry
site (IRES)-mediated initiation, a process that is physiologically important because XIAP …
site (IRES)-mediated initiation, a process that is physiologically important because XIAP …
Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2
Apoptosis can be regulated by extracellular signals that are communicated by peptides such
as fibroblast growth factor 2 (FGF-2) that have important roles in tumor cell proliferation. The …
as fibroblast growth factor 2 (FGF-2) that have important roles in tumor cell proliferation. The …
Identification of a circulating miRNA signature in extracellular vesicles collected from amyotrophic lateral sclerosis patients
…, N Crapoulet, S Fournier, A Ghosh, SM Lewis… - Brain Research, 2019 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated with the
progressive death of motor neurons. Mean survival for a patient diagnosed with ALS is between …
progressive death of motor neurons. Mean survival for a patient diagnosed with ALS is between …
The eIF4G homolog DAP5/p97 supports the translation of select mRNAs during endoplasmic reticulum stress
DAP5/p97 is a member of the eIF4G family of translation initiation factors that has been
suggested to play an important role in the translation of select messenger RNA molecules. We …
suggested to play an important role in the translation of select messenger RNA molecules. We …
Methylarginines within the RGG-motif region of hnRNP A1 affect its IRES trans-acting factor activity and are required for hnRNP A1 stress granule localization and …
ML Wall, SM Lewis - Journal of molecular biology, 2017 - Elsevier
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a stress granule-associated
RNA-binding protein that plays a role in apoptosis and cellular stress recovery. HnRNP A1 is a …
RNA-binding protein that plays a role in apoptosis and cellular stress recovery. HnRNP A1 is a …
A search for structurally similar cellular internal ribosome entry sites
Internal ribosome entry sites (IRES) allow ribosomes to be recruited to mRNA in a cap-independent
manner. Some viruses that impair cap-dependent translation initiation utilize IRES to …
manner. Some viruses that impair cap-dependent translation initiation utilize IRES to …
[HTML][HTML] Characterization of miRNAs in Extracellular vesicles released from Atlantic salmon monocyte-like and macrophage-like cells
Cell-derived extracellular vesicles (EVs) participate in cell-cell communication via transfer of
molecular cargo including genetic material like miRNAs. In mammals, it has previously …
molecular cargo including genetic material like miRNAs. In mammals, it has previously …