BACKGROUND The growing postnatal human heart maintains electromechanical function
while undergoing substantial changes of cellular topology and myocardial architecture. The …

Background—The regional wall motion impairment and predisposition to arrhythmias in
human ventricular hibernation may plausibly result from abnormal intercellular propagation of …

Pancreatic β-cells form highly connected networks within isolated islets. Whether this behaviour
pertains to the situation in vivo, after innervation and during continuous perfusion with …

Plants employ sensor–helper pairs of NLR immune receptors to recognize pathogen
effectors and activate immune responses. Yet, the subcellular localization of NLRs pre- and …

Natural killer (NK) cell responses are regulated by a dynamic equilibrium between activating
and inhibitory receptor signals at the immune synapse (or interface) with target cells. …

… Myocardial slices were blocked overnight at RT in 0.6 M glycine, 1% Triton X-100, 6% Donkey
… Filippo Perbellini and Stephen M Rothery acquired and processed the confocal and two …

Inflammation is recognized as one of the drivers of cancer. Yet, the individual immune
components that possess pro- and anti-tumorigenic functions in individual cancers remain largely …

The aim of this study was to establish, using immunolabeling, whether the Kv1.5 K + channel
is present in the pacemaker of the heart, the sinoatrial (SA) node. In the atrial muscle …

Ischemic heart disease remains the foremost cause of death globally, with survivors at risk
for subsequent heart failure. Paradoxically, cell therapies to offset cardiomyocyte loss after …

Mediastinal lymphadenopathy and auto-antibodies are clinical phenomena during ischemic
heart failure pointing to an autoimmune response against the heart. T and B cells have been …