Objectives: In this cross-sectional study, we tested the construct validity of a “total SVD score,”
which combines individual MRI features of small-vessel disease (SVD) in one measure, by …

The surfaces of bacteria are highly interactive with their environment. Whether the bacterium
is Gram-negative or Gram-positive, most surfaces are charged at neutral pH because of the …

Background Post-stroke cognitive impairment (PSCI) occurs in approximately half of people
in the first year after stroke. Infarct location is a potential determinant of PSCI, but a …

Pseudomonas aeruginosa PAO1 possesses two distinct lipopolysaccharide (LPS) O-polysaccharide
species, A- and B-band LPS, the relative expression of which appears to be under …

Background Cognitive impairment and dementia are common after stroke. It is unclear if risk
differs between ischaemic stroke subtypes. Lacunar strokes might be less likely to affect …

White matter hyperintensities are frequent on neuroimaging of older people and are a key
feature of cerebral small vessel disease. They are commonly attributed to chronic …

Introduction Small vessel disease (SVD) is a common contributor to dementia. Subtle blood-brain
barrier (BBB) leakage may be important in SVD-induced brain damage. Methods We …

White matter hyperintensities accumulate with age and occur in patients with stroke, but their
pathogenesis is poorly understood. We measured multiple magnetic resonance imaging …

Background Cerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial
clinical question is whether cerebral microbleeds indicate patients with recent ischaemic stroke …

There is evidence that subtle breakdown of the blood–brain barrier (BBB) is a pathophysiological
component of several diseases, including cerebral small vessel disease and some …