A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of coronavirus disease 2019 (COVID-19), has …

We demonstrate editing of post-mitotic neurons in the adult mouse brain following injection
of Cas9 ribonucleoprotein (RNP) complexes in the hippocampus, striatum and cortex. …

Rocaglamide A (RocA) typifies a class of protein synthesis inhibitors that selectively kill
aneuploid tumour cells and repress translation of specific messenger RNAs 1 , 2 , 3 , 4 . RocA …

10.7554/eLife.10921.001 Eukaryotic genes generate multiple RNA transcript isoforms though
alternative transcription, splicing, and polyadenylation. However, the relationship between …

CRISPR–Cas genome editing creates targeted DNA double-strand breaks (DSBs) that are
processed by cellular repair pathways, including the incorporation of exogenous DNA via …

A class of translation inhibitors, exemplified by the natural product rocaglamide A (RocA),
isolated from Aglaia genus plants, exhibits antitumor activity by clamping eukaryotic translation …

De novo germline mutations in the RNA helicase DDX3X account for 1%–3% of unexplained
intellectual disability (ID) cases in females and are associated with autism, brain …

Faithful cellular differentiation requires temporally precise activation of gene expression
programs, which are coordinated at the transcriptional and translational levels. Neurons express …

Cap hydrolysis by Dcp2 is a critical step in several eukaryotic mRNA decay pathways.
Processing requires access to cap-proximal nucleotides and the coordinated assembly of a …

Mutations in the RNA helicase, DDX3X, are a leading cause of Intellectual Disability and
present as DDX3X syndrome, a neurodevelopmental disorder associated with cortical …