Understanding the drivers of MHC restriction of T cell receptors
T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-recognition
of peptides presented by MHC molecules. Over the past 20 years, structurally focused …
of peptides presented by MHC molecules. Over the past 20 years, structurally focused …
Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB
SR Daley, DY Hu, CC Goodnow - Journal of Experimental Medicine, 2013 - rupress.org
Acquisition of self-tolerance in the thymus requires T cells to discriminate strong versus
weak T cell receptor binding by self-peptide–MHC complexes. We find this discrimination is …
weak T cell receptor binding by self-peptide–MHC complexes. We find this discrimination is …
SASH3 variants cause a novel form of X-linked combined immunodeficiency with immune dysregulation
Sterile alpha motif (SAM) and Src homology-3 (SH3) domain-containing 3 (SASH3), also
called SH3-containing lymphocyte protein (SLY1), is a putative adaptor protein that is …
called SH3-containing lymphocyte protein (SLY1), is a putative adaptor protein that is …
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
…, K Horikawa, DB Langley, SN Walters, SR Daley… - Nature …, 2019 - nature.com
Resisting and tolerating microbes are alternative strategies to survive infection, but little is
known about the evolutionary mechanisms controlling this balance. Here genomic analyses of …
known about the evolutionary mechanisms controlling this balance. Here genomic analyses of …
Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells
DG Silva, SR Daley, J Hogan, SK Lee, CE Teh… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE To define cellular mechanisms by which B cells promote type 1 diabetes.
RESEARCH DESIGN AND METHODS The study measured islet-specific CD4 T cell regulation in T…
RESEARCH DESIGN AND METHODS The study measured islet-specific CD4 T cell regulation in T…
Cell death and thymic tolerance
SR Daley, C Teh, DY Hu, A Strasser… - Immunological …, 2017 - Wiley Online Library
The differentiation of hematopoietic precursors into the many functionally distinct T‐cell
types produced by the thymus is a complex process. It proceeds through a series of stages …
types produced by the thymus is a complex process. It proceeds through a series of stages …
Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies
SR Daley, KM Coakley, DY Hu, KL Randall, CN Jenne… - elife, 2013 - elifesciences.org
10.7554/eLife.01020.001 Missense variants are a major source of human genetic variation.
Here we analyze a new mouse missense variant, Rasgrp1 Anaef , with an ENU-mutated EF …
Here we analyze a new mouse missense variant, Rasgrp1 Anaef , with an ENU-mutated EF …
αβ T‐cell receptors with a central CDR 3 cysteine are enriched in CD 8αα intraepithelial lymphocytes and their thymic precursors
…, PF Harrison, CC Goodnow, SR Daley - … and Cell Biology, 2018 - Wiley Online Library
The thymus plays a crucial role in immune tolerance by exposing developing T cells (thymocytes)
to a myriad of self‐antigens. Strong T‐cell receptor ( TCR ) engagement induces …
to a myriad of self‐antigens. Strong T‐cell receptor ( TCR ) engagement induces …
[HTML][HTML] Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus
…, NL La Gruta, S Gras, SR Daley - Nature …, 2022 - nature.com
Interactions between a T cell receptor (TCR) and a peptide-major histocompatibility complex
(pMHC) ligand are typically mediated by noncovalent bonds. By studying T cells expressing …
(pMHC) ligand are typically mediated by noncovalent bonds. By studying T cells expressing …
Cysteine and hydrophobic residues in CDR3 serve as distinct T-cell self-reactivity indices
The frequency of TCRa and/or TCRb sequences with cysteine within 2 positions of the CDR3
apex (cysteine index) was also greater in type A IELps than in other thymic and peripheral T…
apex (cysteine index) was also greater in type A IELps than in other thymic and peripheral T…