BACKGROUND: Trace amines, compounds structurally related to classical biogenic amines,
represent endogenous ligands of the trace amine-associated receptor 1 (TAAR1). Because …

Although the neural circuitry underlying homeostatic sleep regulation is little understood,
cortical neurons immunoreactive for neuronal nitric oxide synthase (nNOS) and the neurokinin-…

Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission
by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, …

The hypocretin (orexin) system is involved in sleep/wake regulation, and antagonists of both
hypocretin receptor type 1 (HCRTR1) and/or HCRTR2 are considered to be potential …

Study Objectives: Serotonin (5-HT) has long been implicated in the control of sleep and
wakefulness. This study evaluated the hypnotic efficacy of the 5-HT 6 antagonist RO4368554 (…

Major depressive disorder (MDD) is a serious public health burden and a leading cause of
disability. Its pharmacotherapy is currently limited to modulators of monoamine …

Hypocretin/orexin (Hcrt) is a critical neurotransmitter for the maintenance of wakefulness and
has been implicated in several other functions, including energy metabolism and reward. …

Deficits in sleep and circadian organization have been identified as common early features
in patients with Huntington’s disease that correlate with symptom severity and may be …

γ-Hydroxybutyrate (GHB) is an approved therapeutic for the excessive sleepiness and sudden
loss of muscle tone (cataplexy) characteristic of narcolepsy. The mechanism of action for …

Manual scoring of polysomnography data is labor-intensive and time-consuming, and most
existing software does not account for subjective differences and user variability. Therefore, …