Background One of the global targets for non-communicable diseases is to halt, by 2025,
the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

Analyses of data from genome-wide association studies on unrelated individuals have shown
that, for human traits and diseases, approximately one-third to two-thirds of heritability is …

The contribution of body fat distribution to sleep-disordered breathing in women has not been
examined in detail (to our knowledge). Fifty women under 65 years of age were diagnosed …

The objective of this study was to examine the independent effect of infection with each of
four helminths (Ascaris lumbricoides, Schistosoma japonicum, Necator americanus, and …

Samoans are a unique founder population with a high prevalence of obesity 1 , 2 , 3 , making
them well suited for identifying new genetic contributors to obesity 4 . We conducted a …

Although many cross-sectional studies and a small number of randomized controlled trials
have addressed the relationship between schistosomiasis and anemia, the conflicting results …

Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs)
associated with complex phenotypes. Commonly used RV association tests have …

Length changes in human mitochondrial DNA (mtDNA) are potentially useful markers for
inferring the evolutionary history of populations. One such length change is a nine base pair (9-…