User profiles for Stephen V. Frye
 | Stephen FryeUNC Chapel Hill Verified email at email.unc.edu Cited by 15737 |
[HTML][HTML] Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
Kinase inhibitors have limited success in cancer treatment because tumors circumvent their
action. Using a quantitative proteomics approach, we assessed kinome activity in response …
action. Using a quantitative proteomics approach, we assessed kinome activity in response …
The promise and peril of chemical probes
Chemical probes are powerful reagents with increasing impacts on biomedical research.
However, probes of poor quality or that are used incorrectly generate misleading results. To …
However, probes of poor quality or that are used incorrectly generate misleading results. To …
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
Protein lysine methyltransferases G9a and GLP modulate the transcriptional repression of a
variety of genes via dimethylation of Lys9 on histone H3 (H3K9me2) as well as …
variety of genes via dimethylation of Lys9 on histone H3 (H3K9me2) as well as …
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes
methylation of histone H3 lysine 27 (H3K27). The trimethylation of H3K27 (H3K27me3) is a …
methylation of histone H3 lysine 27 (H3K27). The trimethylation of H3K27 (H3K27me3) is a …
The art of the chemical probe
SV Frye - Nature chemical biology, 2010 - nature.com
Chemical biologists frequently aim to create small-molecule probes that interact with a specific
protein in vitro in order to explore the role of the protein in a broader biological context (…
protein in vitro in order to explore the role of the protein in a broader biological context (…
Discovery of β-Arrestin–Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy
…, NH Jensen, X Che, X Bai, SV Frye… - Proceedings of the …, 2011 - National Acad Sciences
Elucidating the key signal transduction pathways essential for both antipsychotic efficacy
and side-effect profiles is essential for developing safer and more effective therapies. Recent …
and side-effect profiles is essential for developing safer and more effective therapies. Recent …
[HTML][HTML] Too many roads not taken
Most protein research focuses on those known before the human genome was mapped.
Work on the slew discovered since, urge Aled M. Edwards and his colleagues.
Work on the slew discovered since, urge Aled M. Edwards and his colleagues.
Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis
…, SH Dickerson, M Edelstein, SV Frye… - Journal of medicinal …, 2001 - ACS Publications
Two closely related classes of oxindole-based compounds, 1H-indole-2,3-dione 3-phenylhydrazones
and 3-(anilinomethylene)-1,3-dihydro-2H-indol-2-ones, were shown to potently …
and 3-(anilinomethylene)-1,3-dihydro-2H-indol-2-ones, were shown to potently …
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
Among epigenetic “writers”, “readers”, and “erasers”, the lysine methyltransferases G9a and
GLP, which catalyze mono- and dimethylation of histone H3 lysine 9 (H3K9me2) and …
GLP, which catalyze mono- and dimethylation of histone H3 lysine 9 (H3K9me2) and …
The discovery of potent cRaf1 kinase inhibitors
K Lackey, M Cory, R Davis, SV Frye, PA Harris… - Bioorganic & medicinal …, 2000 - Elsevier
A series of benzylidene-1H-indol-2-one (oxindole) derivatives was synthesized and
evaluated as cRaf-1 kinase inhibitors. The key features of the molecules were the donor/acceptor …
evaluated as cRaf-1 kinase inhibitors. The key features of the molecules were the donor/acceptor …