User profiles for Stephen V. Gordon

Stephen V. Gordon

University College Dublin, Ireland
Verified email at ucd.ie
Cited by 27216

A new evolutionary scenario for the Mycobacterium tuberculosis complex

R Brosch, SV Gordon, M Marmiesse… - Proceedings of the …, 2002 - National Acad Sciences
The distribution of 20 variable regions resulting from insertion-deletion events in the
genomes of the tubercle bacilli has been evaluated in a total of 100 strains of Mycobacterium …

The complete genome sequence of Mycobacterium bovis

…, BG Barrell, ST Cole, SV Gordon… - Proceedings of the …, 2003 - National Acad Sciences
Mycobacterium bovis is the causative agent of tuberculosis in a range of animal species
and man, with worldwide annual losses to agriculture of $3 billion. The human burden of …

Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays

SV Gordon, R Brosch, A Billault, T Garnier… - Molecular …, 1999 - Wiley Online Library
Whole‐genome comparisons of the tubercle bacilli were undertaken using ordered bacterial
artificial chromosome (BAC) libraries of Mycobacterium tuberculosis and the vaccine strain, …

Genome plasticity of BCG and impact on vaccine efficacy

R Brosch, SV Gordon, T Garnier… - Proceedings of the …, 2007 - National Acad Sciences
To understand the evolution, attenuation, and variable protective efficacy of bacillus
Calmette–Guérin (BCG) vaccines, Mycobacterium bovis BCG Pasteur 1173P2 has been subjected …

Bottlenecks and broomsticks: the molecular evolution of Mycobacterium bovis

NH Smith, SV Gordon… - Nature Reviews …, 2006 - nature.com
Mycobacterium bovis is the cause of tuberculosis in cattle and is a member of the Mycobacterium
tuberculosis complex. In contrast to many other pathogenic bacterial species, there is …

[HTML][HTML] Conclusive evidence that the major t-cell antigens of themycobacterium tuberculosis complex esat-6 and cfp-10 form a tight, 1: 1 complex and characterization …

…, P Panagiotidou, A Whelan, SV Gordon… - Journal of Biological …, 2002 - ASBMB
The proteins ESAT-6 and CFP-10 have been shown to be secreted by Mycobacterium
tuberculosis and Mycobacterium bovis cells, to be potent T-cell antigens, and to have a clear but …

Structure and function of the complex formed by the tuberculosis virulence factors CFP‐10 and ESAT‐6

…, FW Muskett, G Kelly, TA Frenkiel, SV Gordon… - The EMBO …, 2005 - embopress.org
The secreted Mycobacterium tuberculosis complex proteins CFP‐10 and ESAT‐6 have recently
been shown to play an essential role in tuberculosis pathogenesis. We have determined …

Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosis

…, K Kremer, R Brosch, SV Gordon - Nature Reviews …, 2009 - nature.com
Much effort has been spent trying to work out the origin and history of tuberculosis. Understanding
these concepts could have important consequences for the development of vaccines …

[HTML][HTML] Mycobacterial lineages causing pulmonary and extrapulmonary tuberculosis, Ethiopia

…, L Yamuah, G Hewinson, SV Gordon… - Emerging infectious …, 2013 - ncbi.nlm.nih.gov
Molecular typing of 964 specimens from patients in Ethiopia with lymph node or pulmonary
tuberculosis showed a similar distribution of Mycobacterium tuberculosis strains between the …

Ecotypes of the Mycobacterium tuberculosis complex

…, J Inwald, J Dale, JR Driscoll, SV Gordon… - Journal of theoretical …, 2006 - Elsevier
A phylogeny of the Mycobacterium tuberculosis complex has recently shown that the animal-adapted
strains are found in a single lineage marked by the deletion of chromosomal region …