The ultimate goal of drug product development is to design a system that maximizes the
therapeutic potential of the drug substance and facilitates its access to patients. Pharmaceutical …

Methods were developed to systematically screen different polymer–surfactant combinations
for the purpose of enhancing amorphous active pharmaceutical ingredient (API) solubility …

The partitioning and diffusion behavior of theophylline, vitamin B 12 , and cytochrome c in
physically crosslinked networks of a genetically engineered silk–elastinlike protein-based (…

This review further clarifies the concept of pharmaceutical quality by design (QbD) and
describes its objectives. QbD elements include the following: (1) a quality target product profile (…

Soluplus® is a novel amphiphilic polymer that has been shown to enhance the solubility
and drug dissolution rate of poorly soluble drugs. However, there still is a lack of information …

As outlined in the ICH Q8(R2) guidance, identifying the critical quality attributes (CQA) is a
crucial part of dosage form development; however, the number of possible formulation and …

The influence of environmental conditions such as pH, temperature, and ionic strength on
the equilibrium swelling ratio of physically crosslinked networks of a genetically engineered …

Purpose: Influence of polymers on the polymorphic transition of drugs has received limited
attention in the literature. The main objective of this study was to gain an understanding of the …

Purpose. To assess the miscibility and phase behavior of binary blendsof hydroxypropylmethyl
cellulose (HPMC) with hydroxypropylcellulose (HPC), methylcellulose (MC), and …

Fluid bed is an important unit operation in pharmaceutical industry for granulation and drying.
To improve our understanding of fluid bed granulation, in-line near infrared spectroscopy (…