[HTML][HTML] PROVE—pre-eclampsia obstetric adverse events: establishment of a biobank and database for pre-eclampsia

…, P Herbst, S Schell, T Van Veen, M Belfort, SYC Tong… - Cells, 2021 - mdpi.com
Pre-eclampsia is a leading cause of maternal and perinatal morbidity and mortality. The
burden of disease lies mainly in low-middle income countries. The aim of this project is to …

[HTML][HTML] Comparative M-protein analysis of Streptococcus pyogenes from pharyngitis and skin infections in New Zealand: Implications for vaccine development

…, M Davies, P Carter, A Upton, SYC Tong… - BMC infectious …, 2016 - Springer
Background Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are responsible
for a significant disease burden amongst Māori and Pacific populations in New Zealand (…

Unravelling the complex interplay between antibiotic consumption and adaptive changes in methicillin-resistant Staphylococcus aureus

SJ van Hal, SO Jensen, SYC Tong… - Journal of …, 2024 - academic.oup.com
Objectives This study aims to elucidate the genomic dynamics driving the emergence of
antimicrobial resistance (AMR), with a specific focus on the interplay between AMR and …

YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia

FC Brownfoot, S Tong, NJ Hannan, R Hastie… - Molecular and cellular …, 2015 - Elsevier
… Given its known vasoprotective properties and its ability to block HIF1α we hypothesize that
YC-1 … human tissues to examine the potential of YC-1 as a novel treatment for preeclampsia. …

Phylogenetically Distinct Staphylococcus aureus Lineage Prevalent among Indigenous Communities in Northern Australia

…, AJ Stephens, F Huygens, SYC Tong… - Journal of Clinical …, 2009 - Am Soc Microbiol
The aim was to determine the evolutionary position of the Staphylococcus aureus clonal
complex 75 (CC75) that is prevalent in tropical northern Australia. Sequencing of gap, rpoB, …

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction

…, SE Illanes, J Tu'uhevaha, S Tong - American journal of …, 2016 - Elsevier
… Indeed, the HIF1α inhibitors YC-1 40 and ouabain 41 have been shown to reduce sFlt-1
secretion from placental tissues. However, the safety profile of YC-1 and ouabain in pregnancy …

Expectant management of severe preterm preeclampsia: a comparison of maternal and fetal indications for delivery

SS Mooney, RM Lee, S Tong… - The Journal of Maternal …, 2016 - Taylor & Francis
Objective: To examine the delivery indication (maternal or fetal) for patients with preterm
preeclampsia and assess whether disease characteristics at presentation are predictive of …

The molecular epidemiology of hepatitis B in the Indigenous people of northern A ustralia

…, BC Cowie, DS Bowden, SYC Tong… - Journal of …, 2013 - Wiley Online Library
Background and Aim The hepatitis B surface antigen was first described in the blood of an
Indigenous Australian man, yet little is known about its molecular epidemiology in this …

Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia

S Tong, J Tu'uhevaha, R Hastie, F Brownfoot… - American journal of …, 2022 - Elsevier
There has been increasing research momentum to identify new therapeutic agents for the
prevention or treatment of preeclampsia, drugs that can affect the underlying disease …

[HTML][HTML] Circulating MicroRNAs in maternal blood as potential biomarkers for fetal hypoxia in-utero

…, WT Teh, SP Walker, C Leung, L Larmour, S Tong - PloS one, 2013 - journals.plos.org
Stillbirth affects 1 in 200 pregnancies and commonly arises due to a lack of oxygen supply
to the fetus. Current tests to detect fetal hypoxia in-utero lack the sensitivity to identify many …