Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
…, W Yuan, G Edward, B Homey, M Gilliet, S Ho… - Nature …, 2002 - nature.com
Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2 (T
H 2)-type allergic inflammation is not known. We show here that human thymic stromal …
H 2)-type allergic inflammation is not known. We show here that human thymic stromal …
Structural variation in the sequencing era
Identifying structural variation (SV) is essential for genome interpretation but has been
historically difficult due to limitations inherent to available genome technologies. Detection …
historically difficult due to limitations inherent to available genome technologies. Detection …
Increased survival and function of mesenchymal stem cell spheroids entrapped in instructive alginate hydrogels
SS Ho, KC Murphy, BYK Binder… - Stem cells …, 2016 - academic.oup.com
Mesenchymal stem cell (MSC) spheroids exhibit improved therapeutic potential in vitro
compared with dissociated MSCs, yet spheroids are directly injected into tissues, ceding control …
compared with dissociated MSCs, yet spheroids are directly injected into tissues, ceding control …
Engineering fibrin hydrogels to promote the wound healing potential of mesenchymal stem cell spheroids
Mesenchymal stem cells (MSCs) secrete endogenous factors such as vascular endothelial
growth factor (VEGF) and prostaglandin E2 (PGE 2 ) that promote angiogenesis, modulate …
growth factor (VEGF) and prostaglandin E2 (PGE 2 ) that promote angiogenesis, modulate …
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice
Hepatic stellate cells (HSCs) drive hepatic fibrosis. Therapies that inactivate HSCs have
clinical potential as antifibrotic agents. We previously identified acid ceramidase (aCDase) as …
clinical potential as antifibrotic agents. We previously identified acid ceramidase (aCDase) as …
Whole-genome sequencing analysis of CNV using low-coverage and paired-end strategies is efficient and outperforms array-based CNV analysis
Background Copy number variation (CNV) analysis is an integral component of the study of
human genomes in both research and clinical settings. Array-based CNV analysis is the …
human genomes in both research and clinical settings. Array-based CNV analysis is the …
Comprehensive, integrated, and phased whole-genome analysis of the primary ENCODE cell line K562
K562 is widely used in biomedical research. It is one of three tier-one cell lines of ENCODE
and also most commonly used for large-scale CRISPR/Cas9 screens. Although its functional …
and also most commonly used for large-scale CRISPR/Cas9 screens. Although its functional …
[HTML][HTML] Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
…, C Chen, J Cha, GG Lee, M Rexhepaj, SS Ho… - Respiratory …, 2021 - Springer
Rationale α v integrins, key regulators of transforming growth factor-β activation and fibrogenesis
in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (α v …
in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (α v …
Hypoxic preconditioning of mesenchymal stem cells with subsequent spheroid formation accelerates repair of segmental bone defects
Cell-based approaches for musculoskeletal tissue repair are limited by poor cell survival and
engraftment. Short-term hypoxic preconditioning of mesenchymal stem cells (MSCs) can …
engraftment. Short-term hypoxic preconditioning of mesenchymal stem cells (MSCs) can …
Cell migration and bone formation from mesenchymal stem cell spheroids in alginate hydrogels are regulated by adhesive ligand density
The adhesion and migration of cells entrapped in engineered materials is regulated by
available adhesive ligands. Although mesenchymal stem cell (MSC) spheroids injected into …
available adhesive ligands. Although mesenchymal stem cell (MSC) spheroids injected into …