A key public health need is to identify individuals at high risk for a given disease to enable
enhanced screening or preventive therapies. Because most common diseases have a genetic …

Background Comprehensive long-term data on atrial fibrillation trends in men and women
are scant. We aimed to provide such data through analysis of the Framingham cohort over 50 …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

Background Tools for the prediction of atrial fibrillation ( AF ) may identify high‐risk individuals
more likely to benefit from preventive interventions and serve as a benchmark to test novel …

Background— Atrial fibrillation (AF) and heart failure (HF) frequently coexist and together
confer an adverse prognosis. The association of AF with HF subtypes has not been well …

Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure
and death 1 . We conducted a genome-wide association study (GWAS) in individuals of …

Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have
identified several genetic loci associated with typical AF. We sought to identify common genetic …

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …