User profiles for Steven A. van der Hoek

Steven A. van der Hoek

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Cited by 395

The biology of ergothioneine, an antioxidant nutraceutical

…, E Pretorius, TJ Roberts, SA van der Hoek… - Nutrition Research …, 2020 - cambridge.org
Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …

[HTML][HTML] Transporter engineering in microbial cell factories: the ins, the outs, and the in-betweens

SA van der Hoek, I Borodina - Current opinion in biotechnology, 2020 - Elsevier
… Author links open overlay panel Steven A van der Hoek , Irina Borodina … Steven A van
der Hoek: Conceptualization, Visualization, Writing - original draft. Irina Borodina: …

Engineering energetically efficient transport of dicarboxylic acids in yeast Saccharomyces cerevisiae

…, V Stovicek, SA van Der Hoek… - Proceedings of the …, 2019 - National Acad Sciences
Biobased C4-dicarboxylic acids are attractive sustainable precursors for polymers and other
materials. Commercial scale production of these acids at high titers requires efficient …

[HTML][HTML] Engineering precursor supply for the high-level production of ergothioneine in Saccharomyces cerevisiae

SA van der Hoek, M Rusnák, G Wang, LD Stanchev… - Metabolic …, 2022 - Elsevier
Ergothioneine (ERG) is an unusual sulfur-containing amino acid. It is a potent antioxidant,
which shows great potential for ameliorating neurodegenerative and cardiovascular diseases. …

[HTML][HTML] Engineering the Yeast Saccharomyces cerevisiae for the Production of L-(+)-Ergothioneine

SA Van der Hoek, B Darbani, KE Zugaj… - … in Bioengineering and …, 2019 - frontiersin.org
L-(+)-Ergothioneine (ERG) is an unusual, naturally occurring antioxidant nutraceutical that
has been shown to help reduce cellular oxidative damage. Humans do not biosynthesise ERG…

Engineering ergothioneine production in Yarrowia lipolytica

SA van der Hoek, M Rusnák, IH Jacobsen… - FEBS …, 2022 - Wiley Online Library
Ergothioneine is a naturally occurring antioxidant that has shown potential in ameliorating
neurodegenerative and cardiovascular diseases. In this study, we investigated the potential of …

Deorphanizing solute carriers in Saccharomyces cerevisiae for secondary uptake of xenobiotic compounds

…, J Sáez-Sáez, SA van der Hoek… - Frontiers in …, 2024 - frontiersin.org
The exchange of small molecules between the cell and the environment happens through
transporter proteins. Besides nutrients and native metabolic products, xenobiotic molecules …

The Novel Somatostatin Analog SOM230 Is a Potent Inhibitor of Hormone Release by Growth Hormone- and Prolactin-Secreting Pituitary Adenomas in Vitro

…, J van der Hoek, PM van Koetsveld… - The Journal of …, 2004 - academic.oup.com
To determine the inhibitory profile of the novel somatostatin (SRIF) analog SOM230 with broad
SRIF receptor binding, we compared the in vitro effects of SOM230, octreotide (OCT), and …

Soil macrofauna as indicators of soil quality and land use impacts in smallholder agroecosystems of western Nicaragua

L Rousseau, SJ Fonte, O Téllez, R van der Hoek… - Ecological …, 2013 - Elsevier
The tropical dry forest region along the western slope of Central America represents a
biodiverse and fragile area that is under increasing pressure from agricultural production, thus …

The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5

LJ Hofland, J van der Hoek, R Feelders… - European Journal of …, 2005 - academic.oup.com
Objective Currently, there is no effective medical treatment for patients with pituitary-dependent
Cushing’s disease. A novel somatostatin (SS) analogue, named SOM230, with high …