User profiles for Steven J. Skates
 | Steven SkatesMassachusetts General Hospital Verified email at mgh.harvard.edu Cited by 27634 |
Screening for ovarian cancer
KJ Carlson, SJ Skates, DE Singer - Annals of internal medicine, 1994 - acpjournals.org
Purpose: To critically review the available evidence for screening asymptomatic women for
ovarian cancer with ultrasonography or the CA 125 radioimmunoassay (CA 125) or both. …
ovarian cancer with ultrasonography or the CA 125 radioimmunoassay (CA 125) or both. …
Proteogenomics connects somatic mutations to signalling in breast cancer
Somatic mutations have been extensively characterized in breast cancer, but the effects of
these genetic alterations on the proteomic landscape remain poorly understood. Here we …
these genetic alterations on the proteomic landscape remain poorly understood. Here we …
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma
Verification of candidate biomarkers relies upon specific, quantitative assays optimized for
selective detection of target proteins, and is increasingly viewed as a critical step in the …
selective detection of target proteins, and is increasingly viewed as a critical step in the …
A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass
INTRODUCTION: Patients diagnosed with epithelial ovarian cancer (EOC) have improved
outcomes when cared for at centers experienced in the management of EOC. The objective of …
outcomes when cared for at centers experienced in the management of EOC. The objective of …
[HTML][HTML] Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial
…, AJ McGuire, S Campbell, M Parmar, SJ Skates - The Lancet, 2016 - thelancet.com
Background Ovarian cancer has a poor prognosis, with just 40% of patients surviving 5
years. We designed this trial to establish the effect of early detection by screening on ovarian …
years. We designed this trial to establish the effect of early detection by screening on ovarian …
[HTML][HTML] Integrated proteogenomic characterization of human high-grade serous ovarian cancer
To provide a detailed analysis of the molecular components and underlying mechanisms
associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based …
associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based …
Biomarkers and strategies for early detection of ovarian cancer
…, KH Lu, KS Anderson, CW Drescher, SJ Skates - … Biomarkers & Prevention, 2020 - AACR
Early detection of ovarian cancer remains an important unmet medical need. Effective
screening could reduce mortality by 10%–30%. Used individually, neither serum CA125 nor …
screening could reduce mortality by 10%–30%. Used individually, neither serum CA125 nor …
[HTML][HTML] An analysis of the lowest effective intensity of prophylactic anticoagulation for patients with nonrheumatic atrial fibrillation
EM Hylek, SJ Skates, MA Sheehan… - New England Journal …, 1996 - Mass Medical Soc
Background To avert major hemorrhage, physicians need to know the lowest intensity of
anticoagulation that is effective in preventing stroke in patients with atrial fibrillation. Since the …
anticoagulation that is effective in preventing stroke in patients with atrial fibrillation. Since the …
[HTML][HTML] Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a …
Background Ovarian cancer continues to have a poor prognosis with the majority of women
diagnosed with advanced disease. Therefore, we undertook the UK Collaborative Trial of …
diagnosed with advanced disease. Therefore, we undertook the UK Collaborative Trial of …
[HTML][HTML] Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence …
…, L Fallowfield, N Singh, A Dawnay, SJ Skates… - The lancet …, 2009 - thelancet.com
Background Ovarian cancer has a high case–fatality ratio, with most women not diagnosed
until the disease is in its advanced stages. The United Kingdom Collaborative Trial of …
until the disease is in its advanced stages. The United Kingdom Collaborative Trial of …