DNA mismatch repair is important because of its role in maintaining genomic integrity and
its association with hereditary non-polyposis colon cancer (HNPCC). To identify new human …

Characterlxatlon of several thyroid hormone (T,), retinoic acid, and estrogen response
elements has led to the ldentlflcation of conserved DNA half-sites (core binding motifs). We …

Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the
human microbiome, yet little is known about their role in human cancers. Pan-cancer …

Importance Guidelines for cancer genetic testing based on family history may miss clinically
actionable genetic changes with established implications for cancer screening or prevention…

MutL homolog 3 (Mlh3) is a member of a family of proteins conserved during evolution and
having dual roles in DNA mismatch repair and meiosis 1, 2. The pathway in eukaryotes …

To better understand the molecular mechanisms and genetic basis of human disease, we
systematically examine relationships between 3,949 genes, 62,663 mutations and 3,453 …

Introduction Plummeting sequencing costs have led to a great increase in the number of
personal genomes. Interpreting the large number of variants in them, particularly in noncoding …

microRNAs regulate developmental cell-fate decisions, tissue homeostasis, and oncogenesis
in distinct ways relative to proteins. Here, we show that the tumor suppressor microRNA …

The chr12q24.13 locus encoding OAS1–OAS3 antiviral proteins has been associated with
coronavirus disease 2019 (COVID-19) susceptibility. Here, we report genetic, functional and …

NOTCH signaling is critical for specifying the intestinal epithelial cell lineage and for initiating
colorectal adenomas and colorectal cancers (CRC). Based on evidence that NOTCH is …