The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and
a heightened pro-inflammatory response: two findings that may be intrinsically linked …

In response to NIH initiatives to investigate sex as a biological variable in preclinical animal
studies, researchers have increased their focus on male and female differences in …

… Stewart 1,2 Steven M. MacLean, Steven M. MacLean 1,2 Arnold J. Stromberg Arnold J.
Stromberg 3 Jessica P. …

Spinal cord injury (SCI) is a life-altering event for which there is no treatment. Depending on
injury location and severity, the breadth of the effects can go far past simple mobility. Primary …

Background and Aims Portopulmonary hypertension (POPH) was previously associated
with a single‐nucleotide polymorphism (SNP) rs7175922 in aromatase (cytochrome P450 …

Methods We performed a proof-of-concept open-label pilot study of fulvestrant in PAH. The
trial protocol (see online supplement) was approved by the institutional review board and …

Background Compared to the ‘neutral’ E3, the E4 allele of Apolipoprotein E (APOE) confers
up to a 15‐fold increase in Alzheimer’s Disease (AD) risk. Conversely, the neuroprotective …

Increased risk and severity of idiopathic pulmonary arterial hypertension (iPAH) is
associated with elevated estradiol in men and postmenopausal women. Pulmonary arteries …

Background: Regular corticosteroid has become standard for slowing disease progression
in Duchenne muscular dystrophy (DMD). However, patients must contend with the insidious …

… Stevens … MacLean … maclean …