There is growing appreciation of the role that the extracellular environment plays in regulating
cell behavior. Mechanical, structural, and compositional cues, either alone or in concert, …

Recent evidence has shown that, in addition to rigidity, the viscous response of the
extracellular matrix (ECM) significantly affects the behavior and function of cells. However, the …

Current tissue engineering approaches for tendon defects require improved biomaterials to
balance microstructural and mechanical design criteria. Collagen-glycosaminoglycan (CG) …

Viscoelasticity has emerged as a critical regulator of cell behavior. However, there is an unmet
need to develop biomaterials where viscoelasticity can be spatiotemporally controlled to …

During mesenchymal development, the microenvironment gradually transitions from one
that is rich in cell–cell interactions to one that is dominated by cell–ECM (extracellular matrix) …

Improved fundamental understanding of how cells interpret microenvironmental signals is
integral to designing better biomaterial therapies. YAP/TAZ are key mediators of …

Current surgical and tissue engineering approaches for treating tendon injuries have shown
limited success, suggesting the need for new biomaterial strategies. Here we describe the …

Tissue fibrosis contributes to nearly half of all deaths in the developed world and is
characterized by progressive matrix stiffening. Despite this, nearly all in vitro disease models are …

Biomaterial approaches for engineering orthopedic interfaces such as the tendon‐bone
junction (TBJ) are limited by a lack of understanding of how insoluble (microstructure, …

The extracellular matrix (ECM) presents an evolving set of mechanical cues to resident cells.
We developed methacrylated hyaluronic acid (MeHA) hydrogels containing both stable and …