Clinical trials of novel therapeutics for Alzheimer’s Disease (AD) have consumed a large
amount of time and resources with largely negative results. Repurposing drugs already …

The Hippo signaling pathway has been implicated in mammalian organ size regulation and
tumor suppression. Specifically, the Hippo pathway plays a critical role regulating the activity …

Triggers of innate immune signaling in the CNS of patients with amyotrophic lateral sclerosis
and frontotemporal degeneration (ALS/FTD) remain elusive. We report the presence of …

Metformin, a diabetes drug with anti-aging cellular responses, has complex actions that may
alter dementia onset. Mixed results are emerging from prior observational studies. To …

Objective: This study examined the effects of 2 doses of long-acting risperidone injection in
patients with schizophrenia or schizoaffective disorder. Method: This 52-week, prospective, …

Post-infectious anosmias typically follow death of olfactory sensory neurons (OSNs) with a
months-long recovery phase associated with parosmias. While profound anosmia is the …

The immortalized human ReNcell VM cell line represents a reproducible and easy-to-propagate
cell culture system for studying the differentiation of neural progenitors. To better …

This two-part paper presents the integration of the free-vortex wake method (FVM) with an
aeroelastic framework suitable to model the rotor-wake interactions engendered by floating …

This two-part paper presents the integration of the free-vortex wake method (FVM) into an
aeroelastic framework suitable to model the rotor-wake interactions engendered by floating …

The β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is necessary to generate
the Aβ peptide, which is implicated in Alzheimer's disease pathology. Studies show that the …