The ability of kinesin to travel long distances on its microtubule track without dissociating
has led to a variety of models to explain how this remarkable degree of processivity is …

Purpose: To determine the antitumor efficacy and safety profile of temozolomide in patients
with malignant astrocytoma at first relapse. Patients and Methods: This open-label, …

Kinesin-1 is an ATP-driven, processive motor that transports cargo along microtubules in a
tightly regulated stepping cycle. Efficient gating mechanisms ensure that the sequence of …

Myosin V is an unconventional myosin proposed to be processive on actin filaments, analogous
to kinesin on a microtubule [Mehta, AD, et al. (1999) Nature (London) 400, 590–593]. To …

The proliferative and invasive nature of malignant cancers drives lethality. In glioblastoma,
these two processes are presumed mutually exclusive and hence termed “go or grow.” We …

Cytoplasmic transport is mediated by a group of molecular motors that typically work in isolation,
under conditions where they must move their cargos long distances without dissociating …

Kinesin I can walk on a microtubule for distances as long as several micrometers. However,
it is still unclear how this molecular motor can remain attached to the microtubule through …

The ability of gliomas to invade the brain limits the efficacy of standard therapies. In this study,
we have examined glioma migration in living brain tissue by using two novel in vivo model …

Purpose This multi-institutional phase I trial was designed to determine the maximum-tolerated
dose (MTD) of cilengitide (EMD 121974) and to evaluate the use of perfusion magnetic …

Cell migration, which is central to many biological processes including wound healing and
cancer progression, is sensitive to environmental stiffness, and many cell types exhibit a …